#Over the counter antifungal cream skin#
In addition, most antifungal drugs currently available to treat fungal infections have serious drawbacks, which include low concentration of active ingredients, itching on the skin due to chemical composition, development of fungi resistance and toxic side effects. The erroneous use of antifungal drugs has contributed to frequent resistance experience over the past decades. Superficial and subcutaneous fungal infections are very dangerous if not promptly and properly treated with appropriate drugs. Antifungal drugs play active roles in the treatment of some fungal infections but their misuse always made the fungal infection worsen. The spread of fungal diseases is increasing by overuse of broad-spectrum antibiotics, which lessening non-pathogenic bacterial population that check the growth of fungi through competition. Mycotic diseases are causing significant morbidity and now seen as a serious concern to public health. Conclusionĭevelopment of novel products using bioactive ingredients from plants with commercially available AFCs will serve as potential alternative therapy to cure dermatological infections with no side effects. Combinatory effects of AFCs with TEO or AVG revealed synergistic and indifferent properties. Minimum Inhibitory Concentration (MIC) by AFCs, TEO and AVG ranged from 1.25 to 10.0 mg/ml. AFCs displayed zones of inhibition with values ranged from 5.0 to 14.3 mm, TEO was 5.0 to 11.0 mm and AVG was 8.0 to 11.7 mm against tested fungi. GCMS revealed thirty-six (36) and eighteen (18) bioactive compounds in TEO and AVG, respectively. Phenol, flavonoids, saponins, alkaloids, steroids, terpenoids and cardiac glycosides were present in TEO and AVG. Antifungal activity and synergistic effect of AFCs with TEO or AVG were carried out using agar well diffusion method. Bioactive compounds in plant extracts were compared to known compounds in database library of National Institute of Standards and Technology (U.S.). Phytochemicals and bioactive compounds in TEO and AVG were revealed using GC-MS. This study therefore, revealed antifungal effect of combined Antifungal Creams (AFCs) with Turmeric Essential Oil (TEO) or Aloe vera Gel (AVG).
Combination effect of antibiotic creams with natural products from plants is prospective strategy to produce new antifungal agent. Hence, there is a need to harness the potential of natural bioactive compounds from plant towards treatment of fungal infection. The frequent incidence of fungal infection and widespread of antibiotic resistance are emergent concerns in public health.
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